psychoactive

adjective

psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv 

: affecting the mind or behavior

psychoactive drugs

Examples of psychoactive in a Sentence

Recent Examples on the Web

Tusi is a party drug that typically contains a blend of ketamine, MDMA, and other psychoactive substances, but it is often misrepresented as cocaine. —Isabela Raygoza, Billboard, 13 Aug. 2025

The process releases the psychoactive compound arecoline, which produces a mild stimulant effect – alertness, warmth and a sense of wellbeing. —New Atlas, 4 Aug. 2025

In what McConnell and many other lawmakers see as a loophole in the Farm Bill, hemp operators began offering products with other psychoactive such as delta-8 THC and others. —A.j. Herrington, Forbes.com, 30 July 2025

Delta-8 and delta-9 products can have psychoactive effects, but still contain less than 0.3% THC. —Molly Gregory, The Courier-Journal, 9 June 2025

Word History

First Known Use

1959, in the meaning defined above

Phrases Containing psychoactive

• non-psychoactive

Rhymes for psychoactive

• bioactive
• hyperactive
• interactive
• nonreactive
• overactive
• putrefactive
• retroactive
• unattractive
• unreactive
• vasoactive
• active
• tractive

Kids Definition

psychoactive

adjective

psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv 

: affecting the mind or behavior

psychoactive drugs

Medical Definition

psychoactive

adjective

psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv 

: affecting the mind or behavior

psychoactive drugs

THC is the principal psychoactive ingredient in marijuana